GelrinC Technology

GelrinC Technology

Researchers at Regentis Biomaterials have developed an investigational implant called GelrinC, which is being evaluated as a treatment to help the body regrow cartilage in the knee.

GelrinC is composed of a synthetic material called polyethylene glycol (PEG) and a structurally modified form of human fibrinogen, a protein which in its native form assists healing processes. PEG and native human fibrinogen have been used individually in medical products for many years with excellent results.

GelrinC‘s unique mode of action relies upon its ability to be implanted as a liquid so that it completely fills the defect, and then be cured into a gel that enables the body‘s own stem cells to settle on its surface. Over a period of six to 12 months, the GelrinC is gradually resorbed by the body and replaced by new cartilage tissue.

Watch this video to find out more about how GelrinC works.

Preliminary clinical studies in Europe have indicated that this regenerated tissue provides excellent improvement in pain and function.

GelrinC Procedure

As part of the standard microfracture procedure, GelrinC is applied to the cartilage defect as a liquid and is then exposed to UVA light for 90 seconds. As a result, it turns into a solid, soft implant, completely occupying the space of the defect.

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Watch this video to find out more about the GelrinC procedure.

GelrinC Compared to Other Surgical Treatments

The table below shows how GelrinC compares to other surgical interventions for the treatment of cartilage damage.

Cell-based
Products
Cartilage
Graft
Advanced
Hydrogel
Implant
MACI™ OATS GelrinC
Suitable for All Lesions No No Yes
Number of Surgical Procedures 2 1 1
Requires Removal of Healthy Cartilage Yes Yes No
Requires Advanced Planning Yes
(8-12 weeks)
Sometimes
(2-4 weeks)
No
Procedure Time 1-3 hours 15-45 mins 10 min add-on
to standard
microfracturing
Return to daily activities 4-5 months 6-8 weeks 6-8 weeks